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Interleukin 22 : ウィキペディア英語版 | Interleukin 22
Interleukin-22 (IL-22) is protein that in humans is encoded by the ''IL22'' gene.〔 == Structure ==
IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits.〔 IL-22R is expressed on tissue cells, and it is absent on immune cells. Crystallization is possible if the N-linked glycosylation sites are removed in mutants of IL-22 bound with high-affinity cell-surface receptor sIL-22R1. The crystallographic asymmetric unit contained two IL-22-sIL-22R1 complexes.〔
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